High Protein Diets and Colonic Health Research Paper

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High-Protein Diets and Colon Cancer Risk

High-Protein Diets Increase the Prevalence of Colon Cancer Risk Factors

The increased prevalence of high protein, low carbohydrate diets is evidence of the need for effective weight loss strategies. These diets help individual's lose weight by producing a feeling of satiety that limits calorie intake. The health benefits associated with this type of diet are associated primarily with weight loss and can include improved insulin sensitivity. What is poorly understood is how these diets might affect health in negative ways over the long-term.

Several recent studies have highlighted the role of intestinal flora in mediating colon cancer risk, in particular the metabolic conversion of digestion-resistant carbohydrates (fiber) to short-chain fatty acids through fermentation. One of these short-chain fatty acids, butyrate, serves as the main energy source for the colonic epithelium and has been shown to have anti-inflammatory (reviewed by Russell et al., 2011), anti-proliferative, anti-apoptotic, and anti-neoplastic properties (reviewed by O'Keefe et al., 2007, p. 180S). The enteric fermentation of fiber by bacteria also produces phenolic compounds that have been shown to have antioxidant and anti-neoplastic properties (reviewed by Russell et al., 2011). Nitrosamine and heterocyclic amine production is increased by a diet rich in red meat, in part due to the increased consumption of heme iron, and these byproducts have been linked to an increased risk of colon cancer (reviewed by O'Keefe et al., 2007; Russell et al., 2011).

What has yet to be studied in detail is the effect of high-protein low-carbohydrate diets on colon health, in particular the effects of such a diet on the intestinal biome. The authors (Russell et al., 2011) therefore analyzed the metabolic patterns produced by this popular weight loss diet.

Methodology

The study subjects were obese adult males (N = 17), with a mean body weight of 111.9 kg (264 pounds) and a range of 86.3-154.

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8 kg (190-341 pounds). The mean body mass index (BMI) was 35.8 kg/m2, with a range of 30-48.5). The exclusion criteria were a history of gastrointestinal problems, antibiotic use within the last 3 months, and the use of drugs known to influence fecal microbiota.

Three diets were provided, a weight maintenance diet, high-protein moderate-carbohydrate (HPMC) diet, and a high-protein low-carbohydrate (HPLC) diet. The energy density between the three diets was equivalent. The weight maintenance diet was provided for all subjects at the beginning of the study period for 3-5 days. After the initial maintenance period they were put on either the HPMC or HPLC diet for 28 days. This was a randomized, cross-over study so each subject subsisted on each diet for 28 days during the 9-week study period.

7

Maintenance Diet (5 days):

85 g protein

116 g fat

360 g carbohydrates

HPMC Diet (28 days):

139 g protein

82 g fat

181 g carbohydrates

HPLC Diet (28 days):

137 g protein

143 g fat

22 g carbohydrate

Fresh-frozen fecal matter was analyzed for bacterial counts (fluorescent in situ hybridization) and the concentration of short-chain fatty acids (gas chromatography) and ammonia (VIS spectrophotometry) were determined. Extracted fecal water was analyzed for N-nitroso compound concentrations by assessing nitric oxide release in a thermal energy analyzer. Phenolics, indoles, bile acids, and heterocyclic amines were separated by HPLC (high performance liquid chromatography) and quantified by mass spectrometry.

Results and Summary

The average weight loss experience by the study subjects was 3.59% and 5.77% of body weight for the HPMC and HPLC diets, respectively, which explains why these diets are so popular. In terms of health though, a 50% or 94% reduction in the amount of carbohydrates consumed resulted in 7%.....

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